{"id":39,"date":"2021-06-14T09:40:52","date_gmt":"2021-06-14T08:40:52","guid":{"rendered":"http:\/\/sl-egis2.med.uni-jena.de\/index.php\/2021\/06\/14\/genetic-predisposition-to-the-mortality-in-septic-shock\/"},"modified":"2024-05-30T11:42:05","modified_gmt":"2024-05-30T10:42:05","slug":"genetic-predisposition-to-the-mortality-in-septic-shock","status":"publish","type":"post","link":"http:\/\/www.egis-online.eu\/index.php\/2021\/06\/14\/genetic-predisposition-to-the-mortality-in-septic-shock\/","title":{"rendered":"Genetic Predisposition to the Mortality in Septic Shock"},"content":{"rendered":"<p>A <a href=\"https:\/\/www.mdpi.com\/1422-0067\/22\/11\/5852#\">recent publication by a research group around D. Payen<\/a> sheds light on genetic factors associated with increased mortality risk in septic shock. Besides, environmental factors and comorbidities, genetic predisposition plays a key role in regulation of the host response to infection. By genome-wide association studies, several genes associated with death in patients with septic shock could be identified; Variations in key genes are thought to perturb relevant pathways and thus increase the risk of death in sepsis patients. This is exemplified by a number of significant single nucleotide polymorphisms (SNPs) that were identified within the <em>CISH<\/em> gene, which is involved in cytokine regulation.<\/p>\n<p>Full article:<\/p>\n<p>Rosier F, Brisebarre A, Dupuis C, Baaklini S, Puthier D, Brun C, Pradel LC, Rihet P, Payen D (2021) <a href=\"https:\/\/www.mdpi.com\/1422-0067\/22\/11\/5852#\">Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer<\/a>. International Journal of Molecular Sciences 22: 5852<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent publication by a research group around D. Payen sheds light on genetic factors associated with increased mortality risk in septic shock. Besides, environmental factors and comorbidities, genetic predisposition plays a key role in regulation of the host response to infection. By genome-wide association studies, several genes associated with death in patients with septic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[62,64],"tags":[41,18,21],"class_list":["post-39","post","type-post","status-publish","format-standard","hentry","category-literature","category-publications","tag-genetics","tag-literature","tag-recommendedreading"],"_links":{"self":[{"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/posts\/39","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/comments?post=39"}],"version-history":[{"count":1,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/posts\/39\/revisions"}],"predecessor-version":[{"id":266,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/posts\/39\/revisions\/266"}],"wp:attachment":[{"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/media?parent=39"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/categories?post=39"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/tags?post=39"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}