{"id":421,"date":"2025-01-20T08:48:33","date_gmt":"2025-01-20T07:48:33","guid":{"rendered":"http:\/\/sl-egis2.med.uni-jena.de\/?p=421"},"modified":"2025-01-20T08:51:24","modified_gmt":"2025-01-20T07:51:24","slug":"effectiveness-of-corticosteroid-treatment-in-covid-19-patients-with-different-phenotypes","status":"publish","type":"post","link":"http:\/\/www.egis-online.eu\/index.php\/2025\/01\/20\/effectiveness-of-corticosteroid-treatment-in-covid-19-patients-with-different-phenotypes\/","title":{"rendered":"Effectiveness of corticosteroid-treatment in COVID-19 patients with different phenotypes"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<p>In a recent article in <em>Intensive Care Med<\/em>, EGIS member Matthijs Kox and his team applied machine learning approaches on routine clinical parameters of thousands of critically ill patients affected with COVID-19. Three distinct phenotypes were derived (COVIDICU1-3), each displaying diverse immunological signatures. Only in patients with the hyperinflammatory COVIDICU3 phenotype, late and short-term corticosteroid therapy was not associated with worse survival.<\/p>\n\n\n\n<p>Bruse N et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39186112\/\">Clinical phenotyping uncovers heterogeneous associations between corticosteroid treatment and survival in critically ill COVID-19 patients<\/a>. Intensive Care Med. 2024;50(11):1884-96. DOI: 10.1007\/s00134-024-07593-3<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a recent article in Intensive Care Med, EGIS member Matthijs Kox and his team applied machine learning approaches on routine clinical parameters of thousands of critically ill patients affected with COVID-19. Three distinct phenotypes were derived (COVIDICU1-3), each displaying diverse immunological signatures. Only in patients with the hyperinflammatory COVIDICU3 phenotype, late and short-term corticosteroid [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[62,64],"tags":[34,22,18,17,21],"class_list":["post-421","post","type-post","status-publish","format-standard","hentry","category-literature","category-publications","tag-covid-19","tag-immunophenotyping","tag-literature","tag-publications","tag-recommendedreading"],"_links":{"self":[{"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/posts\/421","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/comments?post=421"}],"version-history":[{"count":3,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/posts\/421\/revisions"}],"predecessor-version":[{"id":424,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/posts\/421\/revisions\/424"}],"wp:attachment":[{"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/media?parent=421"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/categories?post=421"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/tags?post=421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}