{"id":465,"date":"2025-08-01T15:47:59","date_gmt":"2025-08-01T14:47:59","guid":{"rendered":"http:\/\/www.egis-online.eu\/?p=465"},"modified":"2025-10-27T15:49:24","modified_gmt":"2025-10-27T14:49:24","slug":"systemic-inflammation-impairs-myelopoiesis-and-interferon-type-i-responses-in-humans","status":"publish","type":"post","link":"http:\/\/www.egis-online.eu\/index.php\/2025\/08\/01\/systemic-inflammation-impairs-myelopoiesis-and-interferon-type-i-responses-in-humans\/","title":{"rendered":"Systemic inflammation impairs myelopoiesis and interferon type I responses in humans"},"content":{"rendered":"\n<p>In a recent article in <em>Nature Immunology<\/em>, Matthijs Kox and his team describe the dynamic transcriptional and functional landscape of blood and bone marrow&nbsp;leukocytes during the acute hyperinflammatory and late immunosuppressive phases induced by experimental endotoxemia in healthy volunteers. They uncover a critical role for impaired type I IFN signaling in impaired myelopoiesis, a phenomenon that was observed in both the late immunosuppressive phase of endotoxemia and in patients with late-phase sepsis. Importantly, IFN\u03b2 reversed immunosuppression by reinstating the expression of IFN-stimulated genes and cytokine production, and by inducing monocyte maturation. As such, IFN\u03b2 may represent a promising novel treatment option for sepsis. <\/p>\n\n\n\n<p>Keramati F et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40251340\/\">Systemic inflammation impairs myelopoiesis and interferon type I responses in humans.<\/a><em> <\/em><em>Nat Immunol. <\/em>2025 May;26(5):737-747. doi: 10.1038\/s41590-025-02136-4.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a recent article in Nature Immunology, Matthijs Kox and his team describe the dynamic transcriptional and functional landscape of blood and bone marrow&nbsp;leukocytes during the acute hyperinflammatory and late immunosuppressive phases induced by experimental endotoxemia in healthy volunteers. They uncover a critical role for impaired type I IFN signaling in impaired myelopoiesis, a phenomenon [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[62,64],"tags":[18,17,21],"class_list":["post-465","post","type-post","status-publish","format-standard","hentry","category-literature","category-publications","tag-literature","tag-publications","tag-recommendedreading"],"_links":{"self":[{"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/posts\/465","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/comments?post=465"}],"version-history":[{"count":2,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/posts\/465\/revisions"}],"predecessor-version":[{"id":467,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/posts\/465\/revisions\/467"}],"wp:attachment":[{"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/media?parent=465"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/categories?post=465"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.egis-online.eu\/index.php\/wp-json\/wp\/v2\/tags?post=465"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}