Whereas the epidemiology of COVID-19 has dominated the news for months, knowledge of the pathophysiology of the disease remained largely in the background, despite the apparent clinical intricacies of multiple COVID-19 phenotypes.
In a recent review published in Lancet Respiratory Medicine, the European Group on Immunology of Sepsis (EGIS) critically summarizes the most important findings of COVID-19 disease triggered by SARS-CoV-2. The group of authors considers COVID-19 to be a novel viral disease entity with a pronounced vascular inflammatory component, characterized by a dysregulated immune response to the viral infection in severe courses.
Osuchowski MF et al.: The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity. Lancet Respir Med 2021 May 6 DOI: 10.1016/S2213-2600(21)00218-6