A recent publication by a research group around D. Payen sheds light on genetic factors associated with increased mortality risk in septic shock. Besides, environmental factors and comorbidities, genetic predisposition plays a key role in regulation of the host response to infection. By genome-wide association studies, several genes associated with death in patients with septic shock could be identified; Variations in key genes are thought to perturb relevant pathways and thus increase the risk of death in sepsis patients. This is exemplified by a number of significant single nucleotide polymorphisms (SNPs) that were identified within the CISH gene, which is involved in cytokine regulation.
Rosier F, Brisebarre A, Dupuis C, Baaklini S, Puthier D, Brun C, Pradel LC, Rihet P, Payen D (2021) Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer. International Journal of Molecular Sciences 22: 5852