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EGIS quits X
Continue reading →: EGIS quits XAs scientists, we are obligated to be balanced, inquisitive, and to pursue truth using non-aggravating/discriminatory tools. Our pursuit of objective truths (regardless of field of science) encourages a dynamic exchange of information and emergence of friendly disagreements that should lead to ultimate objectivity. We note that the X platform is…
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Obituary, Tomasz Skirecki
Continue reading →: Obituary, Tomasz SkireckiThe EGIS community is devastated and heartbroken by the recent passing of one of its founding members, Tomasz Skirecki. Tomasz passed away peacefully yesterday in his own hospital in Warsaw after a short, aggressive illness. There are no words to express the shock and sadness felt by all of us…
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Effectiveness of corticosteroid-treatment in COVID-19 patients with different phenotypes
Continue reading →: Effectiveness of corticosteroid-treatment in COVID-19 patients with different phenotypesIn a recent article in Intensive Care Med, EGIS member Matthijs Kox and his team applied machine learning approaches on routine clinical parameters of thousands of critically ill patients affected with COVID-19. Three distinct phenotypes were derived (COVIDICU1-3), each displaying diverse immunological signatures. Only in patients with the hyperinflammatory COVIDICU3…
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Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children
Continue reading →: Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in childrenAcute febrile illnesses in children can be secondary to infections or non-infection related inflammatory diseases. Such illness can be life-threatening to children. In this manuscript, we studied immune function at the level of single cells in children with multisystem inflammatory syndrome of childhood (MIS-C) associated with SARS-CoV-2, severe bacterial infection,…
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Review on Advances and Challenges in Sepsis Management
Continue reading →: Review on Advances and Challenges in Sepsis ManagementThe heterogeneity of sepsis poses an immense challenge to the long-term goal of personalising the treatment and management of sepsis patients. Novel techniques and platforms for multidimensional phenotyping of the sepsis patient’s host response have great potential as diagnostic and guiding tools for future sepsis management. In this recent review,…
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Summer School on Acute Medicine at University of Groningen
Continue reading →: Summer School on Acute Medicine at University of GroningenAre you a motivated and research-driven student, eager to learn more about acute medicine? Are you ready to dive into the exciting world of innovations within the Emergency Department (ED)? Join the Summer School on Acute Medicine at the University of Groningen! Over the past decade, the University of Groningen…
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Reframing sepsis immunobiology for translation
Continue reading →: Reframing sepsis immunobiology for translationA current report in Lancet Resp. Med. includes the inaugural definition for the dysregulated immune responses in sepsis and a road map for studying and reclassifying the sepsis-related immune responses to enable drug discovery and targeted treatments. We highlight that many fundamental immunological concepts such as resistance, disease tolerance, resilience, resolution, and repair…
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New review on mechanisms of immune dysregulation in sepsis
Continue reading →: New review on mechanisms of immune dysregulation in sepsisA recent review by the EGIS consortium, published in The Lancet Respiratory Medicine, presents current knowledge and paradigms on mechanisms of immune dysregulation in sepsis. In particular, the EGIS authors discuss conceptual and technical approaches to monitor, evaluate and exploit sepsis-associated immune derangements for the purpose of personalised, high-precision sepsis…
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Post-doctoral position in Infection Biology, Jena
Continue reading →: Post-doctoral position in Infection Biology, JenaThe research group of Translational Infection Medicine at the Leibniz Institute for Natural Product Research and Infection Biology (Jena, Germany) invites talented and highly gifted candidates to apply as Postdoctoral Researcher in Infection Biology. See the full advertisement at the institutes website. The research project focuses on innate immune training, in particular on…
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Post-doctoral position in Immunology, Lyon
Continue reading →: Post-doctoral position in Immunology, LyonA postdoctoral position is open at the Centre de Recherche en Infectiologie at Lyon, France. Scientific focus lies on the role of NLRP3 inflammasome in the immune response to sepsis. See the full job advertisement (pdf) for further information.
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