World Sepsis Day is held on September 13th every year and is an opportunity for people worldwide to unite in the fight against sepsis. Sepsis accounts for at least 7 to 9 million deaths worldwide annually. Yet, depending on country and education, sepsis is known only to 7 – 50 % of the people. Likewise, it is poorly known that sepsis can be prevented by vaccination and clean care and that early recognition and treatment drastically reduces sepsis mortality. This lack of knowledge makes sepsis the number one preventable cause of death worldwide.
EGIS (the European Group on Immunology of Sepsis) is a multidisciplinary group consisting of basic scientists, immunologists, infectious diseases and intensive care medicine specialists with a shared primary research interest in sepsis immunology. Our overarching goal is to develop and foster collaborative research by working in partnership with groups with similar interests, Medical and Scientific Societies, Academia and the Industry. Sepsis was recently redefined by the SEPSIS-3 task force as a life-threatening organ dysfunction caused by a dysregulated host response to infection.
Community-acquired pneumonia (CAP) is the leading cause of sepsis. Whereas the host response has been analyzed regarding innate immunity and inflammatory response, adaptive immunity remained largely unexplored. Méndez et al. aimed to contribute to detailed immunoprofiling in CAP by evaluating the host's adaptive immunity.
Kyriazopoulou E et al. Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis (2017) BMC Medicine 15: 172 This study by the Hellenic Sepsis Study Group investigated the frequency of macrophage activation-like syndrome (MALS) and explored biomarkers of diagnosis and prognosis. Results show that MALS is an independent life-threatening entity in sepsis. Ferritin measurements can provide early diagnosis of MALS and may allow for specific treatment.
A multidisciplinary team of experts in Sepsis, including amongst others anaesthesiologists, immunologists, microbiologists and intensive care specialists, convened at this meeting, held in Valladolid in February 2019. Many interesting talks and engaging discussions covered the topics of sepsis definitions, therapeutic strategies, antibiotics, immunology of sepsis, and critical care of septic patients. The sessions were managed by several experts in these fields.