Bavarian regional parlament has most recently voted for a large, long controversially debated homeopathy study for sepsis treatment, see link below (in German!). Seems like clinical sepsis research will not stagnate any longer…. and rather move backwards.
ZEIT ONLINE: Bayerischer Landtag stimmt für umstrittene Homöopathie-Studie (7. Nov 2019)
Increasing evidence supports a central role of the immune system in sepsis, but the current view of how sepsis affects immunity, and vice versa, is still rudimentary. The European Group on Immunology of Sepsis has identified major gaps that should be addressed with high priority, such as understanding how immunological alterations predispose to sepsis, key aspects of the immunopathological events during sepsis, and the long-term consequences of sepsis on patient's immunity.
This MOOC is aimed to offer the most up-dated information on the cellular and molecular players of innate immunity, and on the mechanisms that lead to the elimination of the pathogens, of either bacterial, viral, fungal or parasitic origin. Accordingly, strategies of the pathogens against the innate immune system are described. The fact that innate immunity is under influence of the genetic evolution, and the microbiota is addressed as well as its crosstalk with the nervous system. Its links with adaptive immunity is also presented.
The article reports on the diagnostic performance of a molecular test (SeptiCyte LAB) to distinguish between sepsis and systemic inflammation of noninfectious etiology in critically ill adults.
The long-term consequences of sepsis on the immune system are currently only scarcely understood. Aiming to promote research on this critical gap, EGIS member Dr. Florian Uhle, together with the journal “Frontiers in Immunology” initiated the research topic “Long-term Consequences of Sepsis and Severe Trauma on Innate and Adaptive Immunity”.
The topic accepts manuscript submission until 16th February 2020. Vladimir Badovinac (Iowa City, USA) and Thomas Griffith (St. Paul, USA), both eminent researcher from the field, serve as further guest editors.
This paper by Kalayci et al. describes an interesting, new, and freely accessible web-based tool for the identification of human genes/proteins involved in disease-associated immune regulation. This might be useful also to research on the immunology of sepsis.