EGIS (the European Group on Immunology of Sepsis) is a multidisciplinary group consisting of basic scientists, immunologists, infectious diseases and intensive care medicine specialists with a shared primary research interest in sepsis immunology. Our overarching goal is to develop and foster collaborative research by working in partnership with groups with similar interests, Medical and Scientific Societies, Academia and the Industry. Sepsis was recently redefined by the SEPSIS-3 task force as a life-threatening organ dysfunction caused by a dysregulated host response to infection.

Homeopathy for sepsis treatment

Submitted by irubio on Wed, 20.11.2019 - 09:34

Bavarian regional parlament has most recently voted for a large, long controversially debated homeopathy study for sepsis treatment, see link below (in German!). Seems like clinical sepsis research will not stagnate any longer…. and rather move backwards.

I. Rubio

ZEIT ONLINE: Bayerischer Landtag stimmt für umstrittene Homöopathie-Studie (7. Nov 2019)

Current gaps in sepsis immunology: new opportunities for translational research

Submitted by mleitner on Tue, 22.10.2019 - 13:21

Increasing evidence supports a central role of the immune system in sepsis, but the current view of how sepsis affects immunity, and vice versa, is still rudimentary. The European Group on Immunology of Sepsis has identified major gaps that should be addressed with high priority, such as understanding how immunological alterations predispose to sepsis, key aspects of the immunopathological events during sepsis, and the long-term consequences of sepsis on patient's immunity.

MOOC Innate Immunity - A new free online course of the Institut Pasteur

Submitted by mleitner on Mon, 14.10.2019 - 09:34

This MOOC is aimed to offer the most up-dated information on the cellular and molecular players of innate immunity, and on the mechanisms that lead to the elimination of the pathogens, of either bacterial, viral, fungal or parasitic origin. Accordingly, strategies of the pathogens against the innate immune system are described. The fact that innate immunity is under influence of the genetic evolution, and the microbiota is addressed as well as its crosstalk with the nervous system. Its links with adaptive immunity is also presented.

Call for participation - Frontiers in Immunology

Submitted by mleitner on Fri, 23.08.2019 - 09:47

The long-term consequences of sepsis on the immune system are currently only scarcely understood. Aiming to promote research on this critical gap, EGIS member Dr. Florian Uhle, together with the journal “Frontiers in Immunology” initiated the research topic “Long-term Consequences of Sepsis and Severe Trauma on Innate and Adaptive Immunity”.

The topic accepts manuscript submission until 16th February 2020. Vladimir Badovinac (Iowa City, USA) and Thomas Griffith (St. Paul, USA), both eminent researcher from the field, serve as further guest editors.

ImmuneRegulation: a web-based tool for identifying human immune regulatory elements

Submitted by mleitner on Mon, 24.06.2019 - 09:22

This paper by Kalayci et al. describes an interesting, new, and freely accessible web-based tool for the identification of human genes/proteins involved in disease-associated immune regulation. This might be useful also to research on the immunology of sepsis.

Characterizing the immunophenotypes of lymphopenic community-acquired pneumonia

Submitted by mleitner on Thu, 18.04.2019 - 09:44
Community-acquired pneumonia (CAP) is the leading cause of sepsis. Whereas the host response has been analyzed regarding innate immunity and inflammatory response, adaptive immunity remained largely unexplored. Méndez et al. aimed to contribute to detailed immunoprofiling in CAP by evaluating the host's adaptive immunity.

Macrophage activation-like syndrome in sepsis

Submitted by mleitner on Tue, 02.04.2019 - 10:44
Kyriazopoulou E et al. Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis (2017) BMC Medicine 15: 172 This study by the Hellenic Sepsis Study Group investigated the frequency of macrophage activation-like syndrome (MALS) and explored biomarkers of diagnosis and prognosis. Results show that MALS is an independent life-threatening entity in sepsis. Ferritin measurements can provide early diagnosis of MALS and may allow for specific treatment.