The immunology of sepsis: translating new insights into clinical practice

Published by

Margit Leitner

September 30, 2025

In a recent review in Nature Reviews Nephrology, Matthijs Kox and a team of international collaborators discuss the state-of-the-art regarding the dysregulated host response in sepsis and conceptual frameworks that help understand this complex response. They advocate for a precision medicine approach, utilizing enrichment strategies, phenotyping, and smarter and flexible trial designs to identify effective immunomodulatory treatment strategies.

Kox M et al. The immunology of sepsis: translating new insights into clinical practice.Nat Rev Nephrol. 2025 Sep 24. doi: 10.1038/s41581-025-01004-6.

European Group on Immunology of Sepsis

We are a multidisciplinary group consisting of basic scientists, immunologists, infectious diseases and intensive care medicine specialists with a shared primary research interest in sepsis immunology. Our overarching goal is to develop and foster collaborative research by working in partnership with groups with similar interests, Medical and Scientific Societies, Academia and the Industry.