The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
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Whereas the epidemiology of COVID-19 has dominated the news for months, knowledge of the pathophysiology of the disease remained largely in the background, despite the apparent clinical intricacies of multiple COVID-19 phenotypes.

In a recent review published in Lancet Respiratory Medicine, the European Group on Immunology of Sepsis (EGIS) critically summarizes the most important findings of COVID-19 disease triggered by SARS-CoV-2…

Whereas the epidemiology of COVID-19 has dominated the news for months, knowledge of the pathophysiology of the disease remained largely in the background, despite the apparent clinical intricacies of multiple COVID-19 phenotypes.

In a recent review published in Lancet Respiratory Medicine, the European Group on Immunology of Sepsis (EGIS) critically summarizes the most important findings of COVID-19 disease triggered by SARS-CoV-2. The group of authors considers COVID-19 to be a novel viral disease entity with a pronounced vascular inflammatory component, characterized by a dysregulated immune response to the viral infection in severe courses.

Osuchowski MF et al.: The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity. Lancet Respir Med 2021 May 6 DOI: 10.1016/S2213-2600(21)00218-6

 

 

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European Group on Immunology of Sepsis

We are a multidisciplinary group consisting of basic scientists, immunologists, infectious diseases and intensive care medicine specialists with a shared primary research interest in sepsis immunology. Our overarching goal is to develop and foster collaborative research by working in partnership with groups with similar interests, Medical and Scientific Societies, Academia and the Industry. 

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